Anti inflammatory MEDs: Definition, Classification, How it works, and The risk of complications – Before discussing about the anti inflammatory drugs, we need to know in advance, what is inflammatory.
What is inflammatory.
Inflammation can be interpreted as inflammatory and divided into two, namely the non-immunological inflammation that does not involve the immune system, for example, physical injuries and wounds. The second is immunological inflammation involving the immune system and an antigen-antibody reaction.
How does non-immunological inflammation occurs? If the body detects inflammatory mediators (e.g. injuries), then the cells in that place will be more easily penetrated and followed by discharge of liquid in the place of inflammation, and swelling occur. The peripheral blood vessels are widening and the flow of blood will be increasingly driven. The red and white blood cells migrate to the defense of the body.
Anti inflammatory MEDs: Nonsteroidal anti-inflammatory drugs
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of drugs used to relieve pain and reduce inflammation, which is characterized by redness of the skin, it feels warm, and swollen. In addition, this remedy can also be used to lower fevers. NSAIDs is often consumed to cope with headaches, menstrual pain, flu, arthritis, joint injuries, or sprains.
NSAIDs work by inhibiting the cyclooxygenase (COX 1 and 2) enzyme to stop the stimulation of hormone prostalglandin, because the hormone that triggers inflammation and amplifies electrical impulses that are sent from the nerves to the brain which increases the pain. By using these drugs, inflammation, pain, or fever that is occuring can be reduced.
Classification of nonsteroidal anti-inflammatory drugs
NSAIDs can be classified based on their chemical structure or mechanism of action. Older NSAIDs are known long before their mechanism of action was described and for this reason it is classified by the chemical structure or origin. New substances are more frequently classified based on their mechanism of action.
- Propionic acid derivatives
- Acetic acid derivatives
- Enolic acid derivatives (Oxicam)
- Antranilic acid derivatives (Fenamat)
- COX-2 selective inhibitors (COBB or Coxibs)
How NSAIDs work
Normally, your body produces chemicals called prostaglandins to heal damaged tissue, protects Your stomach lining from acids and supports the blood clotting platelets. Prostaglandins are produced by an enzyme called cyclooxygenase (COX), which consists of two types: COX I and COX II. Both COX enzymes are responsible for increasing inflammation and fever while only COX I which produces prostaglandins that protect the lining of the stomach and supporting platelets.
NSAIDS work by blocking the COX I and COX II. Because prostaglandins that protect the lining of the stomach and increase blood clotting decreases, NSAIDS can potentially cause stomach ulcers and bleeding. It is recommended to take NSAIDS with food to avoid stomach irritation. COX II inhibitor similar to NSAIDS. They work by blocking the COX II to relieve pain and inflammation. These drugs include celecoxib and rofecoxib.
The risk of complications.
To reduce the risk of side effects or avoiding complications, before giving the NSAIDS, doctors should pay attention to a number of risk factors of the patients, including the presence or absence of a history of gastric disease in patients. In addition, factors of old age.
NSAIDS can also increase the risk of heart and blood vessel complications, especially in patients who have disorders of the heart and blood vessels. The presence or absence of hematological disorders should also be considered.
NSAIDS are commonly used for patients with autoimmune or chronic diseases such as cancer. We have to see the patient. What are the basic diseases that make patients feel pain. For example, due to rheumatoid arthritis (inflammation, soreness, stiffness, and swelling in the joints due to autoimmune disease), inevitably we give NSAIDS. However, risk factors and how long do we have to consider.
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