Glimepiride side effects, and How to use it

By | February 13, 2019
Glimepiride side effects

Glimepiride side effects, and How to use it – Glimepiride is a drug used to control high blood sugar levels in people with type 2 diabetes. This medication works by encouraging the pancreas to produce insulin in the body and help the body use insulin more efficiently. Glimepiride may not be used to treat sufferers of type 1 diabetes, because these drugs can only help lower blood sugar in people with whom are able to naturally produce insulin in their body.

By controlling blood sugar levels, Glimepiride is useful to help prevent kidney failure, diabetic retinopathy, heart attack, or stroke, which is a complication of diabetes.


  • Avoid consuming Glimepiride if you have an allergy to this medicine or sulfonamide class antibiotics..
  • Take care and consult in advance to the doctor if you’re taking or planning any other drugs, including supplements and herbal products.
  • Take care and consult the doctor first if suffering from or have a history of the following conditions:
    • G6PD Deficiency, namely the condition of defective red blood cells due to genetic abnormalities.
    • Hormonal disorders involving the adrenal glands, the pituitary, or thyroid.
    • Heart disease.
    • Kidney disease.
    • Liver disease.
  • Tell the doctor that you are consuming the Glimepiride if you will be undergoing surgery, including dental surgery.
  • Avoid consumption of alco**hol while undergoing treatment with Glimepiride. Alco**hol can cause side effects of Glimepiride got worse.
  • Avoid being too long under sun exposure because of Glimepiride may cause skin sensitivity to sunlight. Use clothes that cover the whole arm, sunglasses, and sunscreen.
  • In case of overdose or allergic reaction after consuming Glimepiride, see a doctor immediately.

How to use Glimepiride.

Take this medicine with breakfast or Your first meal as recommended by your doctor, usually once a day. The dose of the drug is based on the health condition and Your response therapy. To reduce the risk of incidence of side effects, your doctor may recommend that you start this medicine of low dose and increase it gradually. Follow the doctor’s rules carefully.

If you are already using other diabetes drugs (such as chlorpropamide), follow the rules of your doctor carefully to be able to stop the old drugs and started a Glimepiride.

Colesevelam can lower the absorption of Glimepiride. If you use Colesevelam, use Glimepiride for at least 4 hours before using Colesevelam.

Notify the doctor if your condition does not improve or even worsens (your blood sugar levels are too high or too low).

Follow the rules given by the doctor or pharmacist before starting treatment. If you have any questions, consult with your doctor or Your pharmacist.

Glimepiride side effects

The most frequent side effects due to use of Glimepiride is hypoglycemia. Drug interactions that occur generally are also in the form of an increase in Glimepiride side effects.

Side effect.

The main side effects to note on the use of Glimepiride is hypoglycemia.

Common Side effects.

Hypoglycemia can occur in 4-20% Glimepiride user. The Expense of insulin by administering sulfonilurea can occur regardless of the levels of glucose in the blood. Kidney disease can extend the working time of Glimepiride and cause more severe hypoglycemia. Hypoglycemia that occurs can be fatal and are heavy, so the drug needs to be used with caution in geriatric patients.

Less common side effects.

Glimepiride side effects-headaches

Less common side effects are dizziness (1.7%), astenia (1.6%), headaches (1.5%), and nausea (1.1%).

Side effects that are Very rare.

Side effects that are very rare (1%) are skin allergies, skin rash, pruritus, urticaria, diarrhea, abdominal pain, vomiting, anemia, aplastic anemia, agranulocytosis, leukopenia, pancytopenia, thrombocytopenia, cholestasis, impaired liver function, the reaction of Porphyria, and hyponatremia.

Post Marketing reports of Glimepiride Medicine.

  • Serious hypersensitivity reactions, including anaphylaxis, angioedema, and Stevens Johnson Syndrome.
  • Hemolytic anemia in patients with and without G6PD deficiency.
  • Liver disorders (eg, cholestasis, jaundice), as well as hepatitis, which can be progressed to liver failure
  • Porphyria cutanea tarda, photosensitivity reactions and allergic vaskulitis.
  • Leukopenia, agranulocytosis, pancytopenia, and aplastik anemia.
  • Thrombocytopenia (including case weight with the number of platelets < 10,000/MCL) and thrombocytopenic purpura.
  • The reaction of hepatic Porphyria and disulfiram-like reaction
  • Hiponatremia and SIADH, most often in patients on other medications or administering medical conditions known to cause hyponatremia or an increase in the release of antidiuretic hormones.

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