Fecal Transplant For Clostridium Difficile Infections – Kidney or eye donors may have been prevalent in the medical world. But what about the feces transplant?
Maybe it sounds weird. However, this kind of donor does exist and proves to be successful, especially if the donor has “quality” impurities.
Donor stool or feces is a transplant done by a healthy person, by donating his feces to someone who suffers from chronic stomach problems.
Scientists found, this way proved effective in treating this type of indigestion. In a recent study, researchers are looking for ways to identify those called “super donors”‘ or those whose excrement was objectively superior.
Fecal Transplant or Faecal microbiota transplantation for Clostridium difficile infection
Fecal Transplant or Fecal Microbiota Transplantation or FMT is one of the promising methods on recurrent and/or refractory Clostridium difficile infections with high success rate.
A Fecal Microbiota Transplantation is a procedure that performs the “extraction” of feces from healthy humans to humans with certain clinical conditions such as diseases associated with disorders of intestinal microbiota. This procedure is expected to be effective on CDI (Clostridium difficile infection).
Clostridium difficile infections
So far, the Fecal Microbiota Transplantation is indicated on the CDI (Clostridium difficile infection) with a certain indication. At CDI, there is an excessive growth of Clostridium difficile that produces dysbiosis in the intestines. In general, CDI is administered using antibiotics. In addition to treatment, antibiotics also potentially cause further damage to microbiota resulting in a new problem.
Metronidazole and oral vancomycin have become an option since the end of the 1970s for CDI. In severe CDI, Vancomine is more effective than metronidazole. The recurrent incidence rate of CDI is treated with metronidazole and Vancomine is 20.2% and 18.4%. This incidence rate continues to increase from 20% to 60% in 2 or more recurrences.
Recipients, feces and donors
Recommendation from the European Consensus conference on Leucocyte microbiota transplantation in clinical practice on the use of Fecal Microbiota Transplantation for CDI:
- Fecal Microbiota Transplantation is recommended as a treatment option for both light and severe recurrent CDI. (Proof quality: high; Strength Recommendation: Strong)
- Fecal Microbiota Transplantation is considered a treatment option for refractory CDI. (Proof quality: low; Strength recommendation: Strong).
- Not enough evidence to recommend Fecal Microbiota Transplantation as a procedure in the first CDI incident.
In general, older person’s feces are estimated to contain 75% water and 25% solid substance. Most of these solids are organic matter. Estimates of the composition of human feces are: 1011 bacteria, 108 archaea, 108 viruses, 106 fungi, and the rest are metabolites, protists and other unidentified components.
The composition of microbiota is independent of microbiota that can survive (viable) or not. From this composition, most likely bacteria not only become the only player in the Fecal Microbiota Transplantation.
Donors to Fecal Microbiota Transplantation must pass the screening first through a questionnaire. Some examples of points that become the exclusion criteria of donors are:
- Infectious diseases (e.g. HIV, HBV, syphilis, tuberculosis) and a history of activity that is at risk of transmitting infectious diseases,
- History of infections in the intestines,
- Use of illegal drugs,
- Gastrointestinal Tract Disorders,
- Overweight and obesity,
- The use of antibiotics, immunosuppressants and chemotherapy in the last 3 months and chronic therapy with a proton pump inhibitor.
Furthermore, donors that meet the criteria need to be carried out blood screening and feces at least 4 weeks before the donation.
The feces donors that had been screened were then performed a series of procedures. The outline of the procedure is dilution (usually with normal copy), homogenization with Blender, and filtration. Most of these processes use a fresh stool at the time of the donor and during therapy with the recipient. It has been developed the method by which the feces that have been processed are frozen first until the time to be given to the recipient and this procedure has the same effectiveness as fresh feces.
Thank you very much for reading Fecal Transplant For Clostridium Difficile Infections, hopefully useful.
